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What you should do nexta brain protein linked to emotion and fear may explain why some people who suffer high levels of anxiety may be at greater risk of alcoholism, a study has found.The research could help in the development of treatments for both anxiety and alcoholism.Scientists at the university of illinois at chicago(Uic)Found that rats selectively bred to have a preference for alcohol(P rats), had higher anxiety levels and consumed more alcohol than rats that had no preference for alcohol(Np rats).Tests also showed that the alcohol loving p rats displayed lower levels of a protein, called creb, in parts of the brain associated with emotion, fear and anxiety, compared with their teetotal np cousins.One function of the creb protein is to regulate the brain’s production of a molecule that regulates anxiety and alcoholdrinking behaviours.For the p rats, alcohol consumption eased anxiety and increased creb levels.But alcohol did not have a similar effect on the temperate rats.The findings are intriguing, according to dr tingkai li, director of the national institute on alcohol abuse and alcoholism which supported the research. “These experiments help us address questions about the potential role that anxiety might play in human alcoholism”, he said.Rats’ anxiety levels were measured with a piece of apparatus consisting of two open arms and two closed arms connected to a central platform.Rats who spend more time in the closed arms were judged to be more anxious.The researchers showed that chemically stimulating creb activity in the parts of the brain associated with anxiety could decrease the anxiety and alcohol intake in p rats.And chemically blocking creb prompted np rats to display anxious behaviour and turn to alcohol.Lead researcher subhash pandey said that the p rats appear to selfmedicate with alcohol to alleviate anxiety, a behaviour often seen in humans.The research suggests a deficit of the creb brain protein in people who are genetically predisposed to anxiety and alcohol drinking behaviours, Clarisonic PLUS he said. “This is the first direct evidence that a hereditary deficiency of creb protein is associated with high anxiety and alcoholdrinking behaviours,”Said dr pandey, who is director of neuroscience alcoholism research at the uic college of medicine.Results of the study are published in this month’s issue of the journal of clinical investigation.Adfero ltd

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Boston marathon bomb blasts kill 3

Two deadly bombs exploded near the boston marathon finish line on monday, killing at least three, injuring more than 140, and severing the limbs of a number of people, police and hospital officials say.

Photos:Boston marathon explosions”It is a criminal investigation that is a potential terrorist investigation,”Fbi special agentrick deslauriers said in a news conference.Any responsible individuals, any responsible groups will feel the full weight of justice. ”

So far, therehas beenno word on the motive or who may have launched the attack.

State police said that a search warrant related to the investigation was served monday night in the boston suburb of revere, but provided no further details.Investigators were seen leaving the revere house early tuesday carrying brown paper bags, plastic trash bags and a duffel bag, according to ap.

Following obama’s remarks, one white house official said that”Any event with multiple explosive devicesas this appears to beis clearly an act of terror, and will be approached as an act of terror. ”

Boston police department commissioner ed davis said that at least moncler coats men three people were killed in the blasts but that they won’t have specific figures about casualties until tuesday.There were reports that one of those killed was an eightyearold boy.

The associated press reported that eight hospitalssaid that they are treating at least 144 people.Of those, at least 17 are in critical condition.The injuries ranged from cuts and bruises to amputations.Many victims suffered lower leg injuries and shrapnel wounds.Some suffered ruptured eardrums.

Dr.Richard wolfe, chief of the department of emergency medicine at beth israel deaconess medical center, Great Deals said one or two of the hospital’s 21 patients faced a”High probability of mortality. ”

Dr.Peter fagenholz, of massachusetts general hospital, said monday thathis hospital had treated 29 patients and chick here that eight were in critical condition.Many of the injuries were to the lower limbs.

“Yes, we have performed several amputations,”Fagenholz confirmed.

He addedthat they were seeing signs of shrapneltype injuries, butcouldn’t say if it was from the explosive devices.

Foreign true religion denim shorts affairs officialstold cbc newsthat so far there have been no reports of any canadians injured in the blasts.Emergency workers and national guardsmen assigned to the race for crowd control began climbing over and tearing down temporary fences to get to the blast site.Intelligence official who spoke tothe apon condition of anonymity because of the continuing investigation.Kennedy presidential library and museum that was initially thought to be another blast was being treated as a fire and not believed to berelated to the two bombings.

‘Crying as they fled the chaos’Competitors and race organizers were crying as they fled the chaos.Bloody spectators were carried to the medical tent that had been set up to care for fatigued runners.

“I started running toward Clarisonic the blast.And there were people all over the floor,”He told the associated press. “We started grabbing tourniquets and started tying legs.A lot of people amputated.At least 25 to 30 people have at least one leg missing, or an ankle missing, or two legs missing. ”

“They just started bringing people in with no limbs,”Runner tim davey, of Michael Kors Handbags Sale richmond, va., told the Associated Press.He said he and his wife, lisa, tried to keep their children’s eyes shielded from the gruesome scene inside a medical tent that had been set up to care for fatigued runners, but”They saw a lot. ”

“They just kept filling up with more and more casualties,”Lisa davey said. “Most everybody was conscious.They were very dazed. ”

According to the boston marathon website, 2, 078 canadians were listed as entrants among the 27, 000 people in the race.

Michael doyle, a canadian who was in the marathon, said he heard sirens and”Quite a bit of commotion”On monday afternoon. “Then i heard there were two explosions, one of them close to the finishline, another further up. ”

“It’s [a] very surreal situation,”The web producer for canadian running magazinetold cbc news.

“As i was making my way closer to the scene here, it was a mixture of people who were very upset and crying, and who seemed to be cognizant of what was going on, and those who i think were completely unaware of the situation,”He said.

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Tupac amaru shakur, whose murder remains unsolved 15 years after he was shot in las vegas, would have turned 40 on june 16.Universal has reissued five 2pac albums in digital form this week to mark the iconic rapper’s birthday.And 1995’s multiplatinum me against Cheap Louis Vuitton Handbags the world, his first charttopper.Also available are 1994’s thug Clarisonic PLUS life:Volume 1, the debut by the gangsta rap group 2pac founded, and 1997’s r u still down? (Remember me), the second in a long string of posthumous albums.It was the first to bear no artistic input from 2pac and the first released on his mother’s label, amaru entertainment.Edna gundersen

The beat goes on for blondie, as debbie harry and bandmates prepare Michael Kors Handbags to hit the road this fall.Harry, fellow original members chris stein and clem burke and a few newer colleagues will tour behind a ninth studio album, panic of girls, out sept.13 on the group’s own imprint.Tickets go on sale friday for a series of shows kicking off sept.4 in Prior Lake, Minn.The trek true religion - official will touch down in chicago, new york, boston, new orleans, dallas, phoenix, los angeles and other cities before wrapping oct.8 in Las Vegas.Elysa gardner

Lynyrd skynyrd’s ronnie van zant once famously asked,”What song is it you want to hear? “On their upcoming musical ride tour, the three hanson brothers want their fans to answer the same question about an entire album.Starting monday, hanson fans will be able to vote for which of the group’s five albums, including latest release shout it out, the band will perform in its entirety at a given tour stop.Tickets go on sale friday for the tour, which kicks off sept.4 in Seattle.Mansfield

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